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Dokumenttyp:
journal article 
Autor(en):
Tarangelo, Amy; Lo, Nathanael; Teng, Rebecca; Kim, Eunsun; Le, Linh; Watson, Deborah; Furth, Emma E; Raman, Pichai; Ehmer, Ursula; Viatour, Patrick 
Titel:
Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression. 
Abstract:
Changes in gene expression during tumorigenesis are often considered the consequence of de novo mutations occurring in the tumour. An alternative possibility is that the transcriptional response of oncogenic transcription factors evolves during tumorigenesis. Here we show that aberrant E2f activity, following inactivation of the Rb gene family in a mouse model of liver cancer, initially activates a robust gene expression programme associated with the cell cycle. Slowly accumulating E2f1 progress...    »
 
Zeitschriftentitel:
Nat Commun 
Jahr:
2015 
Band / Volume:
Seitenangaben Beitrag:
10028 
Sprache:
eng 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik