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Dokumenttyp:
journal article 
Autor(en):
Groß, Claudia; Steiger, Katja; Sayyed, Sufyan; Heid, Irina; Feuchtinger, Annette; Walch, Axel; Heß, Julia; Unger, Kristian; Zitzelsberger, Horst F; Settles, Markus; Schlitter, Anna Melissa; Dworniczak, Juliane; Altomonte, Jennifer; Ebert, Oliver; Schwaiger, Markus; Rummeny, Ernst J; Steingötter, Andreas; Esposito, Irene; Braren, Rickmer 
Titel:
Model Matters: Differences in Orthotopic Rat Hepatocellular Carcinoma Physiology Determine Therapy Response to Sorafenib. 
Abstract:
Preclinical model systems should faithfully reflect the complexity of the human pathology. In hepatocellular carcinoma (HCC), the tumor vasculature is of particular interest in diagnosis and therapy. By comparing two commonly applied preclinical model systems, diethylnitrosamine induced (DEN) and orthotopically implanted (McA) rat HCC, we aimed to measure tumor biology noninvasively and identify differences between the models.DEN and McA tumor development was monitored by MRI and PET. A slice-ba...    »
 
Zeitschriftentitel:
Clin Cancer Res 
Jahr:
2015 
Band / Volume:
21 
Heft / Issue:
19 
Seitenangaben Beitrag:
4440-50 
Sprache:
eng 
Print-ISSN:
1078-0432 
TUM Einrichtung:
Institut für Radiologie; Institut für Allgemeine Pathologie und pathologische Anatomie; II. Medizinische Klinik und Poliklinik; Nuklearmedizinische Klinik und Poliklinik