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Dokumenttyp:
journal article 
Autor(en):
Jochheim, David; Zadrozny, Magda; Theiss, Hans; Baquet, Moritz; Maimer-Rodrigues, Fatima; Bauer, Axel; Lange, Philipp; Greif, Martin; Kupatt, Christian; Hausleiter, Jörg; Hagl, Christian; Massberg, Steffen; Mehilli, Julinda 
Titel:
Aortic regurgitation with second versus third-generation balloon-expandable prostheses in patients undergoing transcatheter aortic valve implantation. 
Abstract:
Our aim was to assess the incidence of aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) with the second (SXT) versus third-generation (S3) balloon-expandable SAPIEN prosthesis in patients with symptomatic aortic stenosis (AS).Of 634 patients undergoing TAVI in our centre from May 2010 to July 2014, 354 were treated with the SXT and 100 with the S3 prosthesis. The primary outcome was the incidence of more-than-mild post-TAVI AR at discharge. Secondary outcomes were 30-day incidence of all-cause death, any bleeding complications and need for new pacemaker. The incidence of the primary outcome was 2.0% vs. 8.8%, p<0.01 with S3 compared to SXT, and S3 use was the only independent predictor of post-TAVI AR (odds ratio 0.54; 95% CI: 0.33 to 0.89). At 30 days, there were no differences in mortality (1.0% vs. 4.2%, p=0.13) and pacemaker rate (12.0% vs. 10.5%, p=0.59) between S3 and SXT. S3-treated patients less frequently had bleeding complications (24.0% vs. 41.8%, p<0.01) and more often had permanent new left bundle branch block (22.0% vs. 7.1%, p<0.001).Compared to the SXT, the use of the S3 prosthesis substantially reduces post-TAVI aortic regurgitation. Longer follow-up is needed to assess if this finding translates to better clinical outcomes. 
Zeitschriftentitel:
EuroIntervention 
Jahr:
2015 
Band / Volume:
11 
Heft / Issue:
Seitenangaben Beitrag:
214-20 
Sprache:
eng 
Print-ISSN:
1774-024X 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik