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Dokumenttyp:
journal article 
Autor(en):
Orban, Mathias; Goedel, Alexander; Haas, Jessica; Sandrock-Lang, Kirstin; Gärtner, Florian; Jung, Christian Billy; Zieger, Barbara; Parrotta, Elvira; Kurnik, Karin; Sinnecker, Daniel; Wanner, Gerhard; Laugwitz, Karl-Ludwig; Massberg, Steffen; Moretti, Alessandra 
Titel:
Functional comparison of induced pluripotent stem cell- and blood-derived GPIIbIIIa deficient platelets. 
Abstract:
Human induced pluripotent stem cells (hiPSCs) represent a versatile tool to model genetic diseases and are a potential source for cell transfusion therapies. However, it remains elusive to which extent patient-specific hiPSC-derived cells functionally resemble their native counterparts. Here, we generated a hiPSC model of the primary platelet disease Glanzmann thrombasthenia (GT), characterized by dysfunction of the integrin receptor GPIIbIIIa, and compared side-by-side healthy and diseased hiPS...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2015 
Band / Volume:
10 
Heft / Issue:
Seitenangaben Beitrag:
e0115978 
Sprache:
eng 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik; Lehrstuhl für Regenerative Medizin bei kardiovaskulären Erkrankungen