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Dokumenttyp:
journal article 
Autor(en):
Lichtenauer, Urs D; Di Dalmazi, Guido; Slater, Emily P; Wieland, Thomas; Kuebart, Anne; Schmittfull, Anett; Schwarzmayr, Thomas; Diener, Susanne; Wiese, Dominik; Thasler, Wolfgang E; Reincke, Martin; Meitinger, Thomas; Schott, Matthias; Fassnacht, Martin; Bartsch, Detlef K; Strom, Tim M; Beuschlein, Felix 
Titel:
Frequency and clinical correlates of somatic Ying Yang 1 mutations in sporadic insulinomas. 
Abstract:
Insulinomas represent pancreatic neuroendocrine neoplasms that cause severe morbidity attributed to their often pronounced endocrine activity. Apart from hereditary forms such as multiple endocrine neoplasia type 1 (MEN-1), genetic causes for sporadic insulinoma development had remained obscure until recently. Applying next-generation sequencing methods, disease-causing genetic alterations have been identified in various endocrine tumors.Paired tumor and blood DNA from eight patients with sporad...    »
 
Zeitschriftentitel:
J Clin Endocrinol Metab 
Jahr:
2015 
Band / Volume:
100 
Heft / Issue:
Seitenangaben Beitrag:
E776-82 
Sprache:
eng 
Print-ISSN:
0021-972X 
TUM Einrichtung:
Institut für Humangenetik