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- Document type:
- Journal Article; Journal Article
- Author(s):
- Schulte, Eva C; Kurz, Alexander; Alexopoulos, Panagiotis; Hampel, Harald; Peters, Annette; Gieger, Christian; Rujescu, Dan; Diehl-Schmid, Janine; Winkelmann, Juliane
- Title:
- Excess of rare coding variants in PLD3 in late- but not early-onset Alzheimer's disease.
- Abstract:
- Recently, mutations in phospholipase D3 (PLD3) were reported in late-onset Alzheimer's disease (AD). By screening the coding regions of PLD3 for variants in a European cohort of 1,089 AD cases, 182 individuals with frontotemporal lobar degeneration and 1,456 controls, we identified 32 variants with a minor allele frequency <5% and observed an excess of rare variants in individuals with late- but not early-onset AD (P=0.034, ? (2)-test; odds ratio=1.46).
- Journal title abbreviation:
- Hum Genome Var
- Year:
- 2015
- Journal volume:
- 2
- Pages contribution:
- 14028
- Language:
- eng
- Fulltext / DOI:
- doi:10.1038/hgv.2014.28
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/27081517
- Print-ISSN:
- 2054-345X
- TUM Institution:
- Institut für Humangenetik; Klinik und Poliklinik für Psychiatrie und Psychotherapie
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