Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Schulte, Eva C; Kurz, Alexander; Alexopoulos, Panagiotis; Hampel, Harald; Peters, Annette; Gieger, Christian; Rujescu, Dan; Diehl-Schmid, Janine; Winkelmann, Juliane 
Titel:
Excess of rare coding variants in PLD3 in late- but not early-onset Alzheimer's disease. 
Abstract:
Recently, mutations in phospholipase D3 (PLD3) were reported in late-onset Alzheimer's disease (AD). By screening the coding regions of PLD3 for variants in a European cohort of 1,089 AD cases, 182 individuals with frontotemporal lobar degeneration and 1,456 controls, we identified 32 variants with a minor allele frequency<5% and observed an excess of rare variants in individuals with late- but not early-onset AD (P=0.034, ? (2)-test; odds ratio=1.46). 
Zeitschriftentitel:
Hum Genome Var 
Jahr:
2015 
Band / Volume:
Seitenangaben Beitrag:
14028 
Sprache:
eng 
Print-ISSN:
2054-345X 
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie; Institut für Humangenetik