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Document type:
journal article 
Author(s):
Schulte, Eva C; Kurz, Alexander; Alexopoulos, Panagiotis; Hampel, Harald; Peters, Annette; Gieger, Christian; Rujescu, Dan; Diehl-Schmid, Janine; Winkelmann, Juliane 
Title:
Excess of rare coding variants in PLD3 in late- but not early-onset Alzheimer's disease. 
Abstract:
Recently, mutations in phospholipase D3 (PLD3) were reported in late-onset Alzheimer's disease (AD). By screening the coding regions of PLD3 for variants in a European cohort of 1,089 AD cases, 182 individuals with frontotemporal lobar degeneration and 1,456 controls, we identified 32 variants with a minor allele frequency<5% and observed an excess of rare variants in individuals with late- but not early-onset AD (P=0.034, ? (2)-test; odds ratio=1.46). 
Journal title abbreviation:
Hum Genome Var 
Year:
2015 
Journal volume:
Pages contribution:
14028 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
2054-345X 
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie; Institut für Humangenetik