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Dokumenttyp:
journal article 
Autor(en):
Kobuch, Julia; Cui, Haissi; Grünwald, Barbara; Saftig, Paul; Knolle, Percy A; Krüger, Achim 
Titel:
TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice. 
Abstract:
The homeostasis of neutrophil granulocytes can affect the outcome of several inflammation-associated diseases including cancer. The regulation of this homeostasis is still not completely understood. We previously found that elevated systemic levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) induce an increase of neutrophils in the liver, which in turn strongly promotes liver metastasis. Here, we report that increasing systemic TIMP-1 levels were sufficient to induce neutrophilia in mic...    »
 
Zeitschriftentitel:
Haematologica 
Jahr:
2015 
Band / Volume:
100 
Heft / Issue:
Seitenangaben Beitrag:
1005-13 
Sprache:
eng 
Print-ISSN:
0390-6078 
TUM Einrichtung:
Institut für experimentelle Onkologie und Therapieforschung; Institut für Molekulare Immunologie