Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Ilmer, Matthias; Boiles, Alejandro Recio; Regel, Ivonne; Yokoi, Kenji; Michalski, Christoph W; Wistuba, Ignacio I; Rodriguez, Jaime; Alt, Eckhard; Vykoukal, Jody 
Titel:
RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells. 
Abstract:
Cancer stem cells (CSC) present a formidable clinical challenge by escaping therapeutic intervention and seeding tumors through processes that remain incompletely understood. Here, we describe small subpopulations of pancreatic cancer cells with high intrinsic Wnt activity (Wnt(high)) that possess properties indicative of CSCs, including drug resistance and tumor-initiating capacity, whereas cell populations with negligible Wnt activity (Wnt(low)) preferentially express markers of differentiatio...    »
 
Zeitschriftentitel:
Cancer Res 
Jahr:
2015 
Band / Volume:
75 
Heft / Issue:
Seitenangaben Beitrag:
1883-96 
Sprache:
eng 
Print-ISSN:
0008-5472 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik