Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Cioffi, Michele; Trabulo, Sara; Hidalgo, Manuel; Costello, Eithne; Greenhalf, William; Erkan, Mert; Kleeff, Joerg; Sainz, Bruno; Heeschen, Christopher 
Titel:
Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms. 
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is a cancer of the exocrine pancreas with unmet medical need and is strongly promoted by tumor-associated macrophages (TAM). The presence of TAMs is associated with poor clinical outcome, and their overall role, therefore, appears to be protumorigenic. The "don't eat me" signal CD47 on cancer cells communicates to the signal regulatory protein-? on macrophages and prevents their phagocytosis. Thus, inhibition of CD47 may offer a new opportunity to turn TAM...    »
 
Zeitschriftentitel:
Clin Cancer Res 
Jahr:
2015 
Band / Volume:
21 
Heft / Issue:
10 
Seitenangaben Beitrag:
2325-37 
Sprache:
eng 
Print-ISSN:
1078-0432 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik