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Document type:
journal article 
Author(s):
Kong, Bo; Cheng, Tao; Wu, Weiwei; Regel, Ivonne; Raulefs, Susanne; Friess, Helmut; Erkan, Mert; Esposito, Irene; Kleeff, Jörg; Michalski, Christoph W 
Title:
Hypoxia-induced endoplasmic reticulum stress characterizes a necrotic phenotype of pancreatic cancer. 
Abstract:
Stromal fibrosis and tissue necrosis are major histological sequelae of hypoxia. The hypoxia-to-fibrosis sequence is well-documented in pancreatic ductal adenocarcinoma (PDAC). However, hypoxic and necrotic PDAC phenotypes are insufficiently characterized. Recently, reduction of tuberous sclerosis expression in mice together with oncogenic Kras demonstrated a rapidly metastasizing phenotype with histologically eccentric necrosis, transitional hypoxia and devascularisation. We established cell li...    »
 
Journal title abbreviation:
Oncotarget 
Year:
2015 
Journal volume:
Journal issue:
31 
Pages contribution:
32154-60 
Language:
eng 
Fulltext / DOI:
TUM Institution:
Chirurgiesche Klinik und Poliklinik