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Dokumenttyp:
journal article 
Autor(en):
Diakopoulos, Kalliope N; Lesina, Marina; Wörmann, Sonja; Song, Liang; Aichler, Michaela; Schild, Lorenz; Artati, Anna; Römisch-Margl, Werner; Wartmann, Thomas; Fischer, Robert; Kabiri, Yashar; Zischka, Hans; Halangk, Walter; Demir, Ihsan Ekin; Pilsak, Claudia; Walch, Axel; Mantzoros, Christos S; Steiner, Jörg M; Erkan, Mert; Schmid, Roland M; Witt, Heiko; Adamski, Jerzy; Algül, Hana 
Titel:
Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes. 
Abstract:
Little is known about the mechanisms of the progressive tissue destruction, inflammation, and fibrosis that occur during development of chronic pancreatitis. Autophagy is involved in multiple degenerative and inflammatory diseases, including pancreatitis, and requires the protein autophagy related 5 (ATG5). We created mice with defects in autophagy to determine its role in pancreatitis.We created mice with pancreas-specific disruption of Atg5 (Ptf1aCreex1; Atg5F/F mice) and compared them to cont...    »
 
Zeitschriftentitel:
Gastroenterology 
Jahr:
2015 
Band / Volume:
148 
Heft / Issue:
Seitenangaben Beitrag:
626-638.e17 
Sprache:
eng 
Print-ISSN:
0016-5085 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik; Chirurgiesche Klinik und Poliklinik; Klinik für Ernährungsmedizin