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Dokumenttyp:
journal article 
Autor(en):
Seubert, Bastian; Grünwald, Barbara; Kobuch, Julia; Cui, Haissi; Schelter, Florian; Schaten, Susanne; Siveke, Jens T; Lim, Ngee H; Nagase, Hideaki; Simonavicius, Nicole; Heikenwalder, Mathias; Reinheckel, Thomas; Sleeman, Jonathan P; Janssen, Klaus-Peter; Knolle, Percy A; Krüger, Achim 
Titel:
Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice. 
Abstract:
Due to its ability to inhibit prometastatic matrix metalloproteinases, tissue inhibitor of metalloproteinases (TIMP)-1 has been thought to suppress tumor metastasis. However, elevated systemic levels of TIMP-1 correlate with poor prognosis in cancer patients, suggesting a metastasis-stimulating role of TIMP-1. In colorectal cancer patients, tumor as well as plasma TIMP-1 levels were correlated with synchronous liver metastasis or distant metastasis-associated disease relapse. In mice, high syste...    »
 
Zeitschriftentitel:
Hepatology 
Jahr:
2015 
Band / Volume:
61 
Heft / Issue:
Seitenangaben Beitrag:
238-48 
Sprache:
eng 
Print-ISSN:
0270-9139 
TUM Einrichtung:
Institut für Virologie; Institut für experimentelle Onkologie und Therapieforschung; II. Medizinische Klinik und Poliklinik; Chirurgiesche Klinik und Poliklinik; Institut für Molekulare Immunologie