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Dokumenttyp:
journal article 
Autor(en):
Andreetto, Erika; Malideli, Eleni; Yan, Li-Mei; Kracklauer, Michael; Farbiarz, Karine; Tatarek-Nossol, Marianna; Rammes, Gerhard; Prade, Elke; Neumüller, Tatjana; Caporale, Andrea; Spanopoulou, Anna; Bakou, Maria; Reif, Bernd; Kapurniotu, Aphrodite 
Titel:
A Hot-Segment-Based Approach for the Design of Cross-Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self-Assembly. 
Abstract:
The design of inhibitors of protein-protein interactions mediating amyloid self-assembly is a major challenge mainly due to the dynamic nature of the involved structures and interfaces. Interactions of amyloidogenic polypeptides with other proteins are important modulators of self-assembly. Here we present a hot-segment-linking approach to design a series of mimics of the IAPP cross-amyloid interaction surface with A? (ISMs) as nanomolar inhibitors of amyloidogenesis and cytotoxicity of A?, IAPP...    »
 
Zeitschriftentitel:
Angew Chem Int Ed Engl 
Jahr:
2015 
Band / Volume:
54 
Heft / Issue:
44 
Seitenangaben Beitrag:
13095-100 
Sprache:
eng 
Print-ISSN:
0570-0833 
TUM Einrichtung:
Klinik für Anästhesiologie