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Document type:
journal article 
Author(s):
Franke, Katharina; Vilne, Baiba; Prazeres da Costa, Olivia; Rudelius, Martina; Peschel, Christian; Oostendorp, Robert A J; Keller, Ulrich 
Title:
In vivo hematopoietic Myc activation directs a transcriptional signature in endothelial cells within the bone marrow microenvironment. 
Abstract:
Cancer pathogenesis involves tumor-intrinsic genomic aberrations and tumor-cell extrinsic mechanisms such as failure of immunosurveillance and structural and functional changes in the microenvironment. Using Myc as a model oncogene we established a conditional mouse bone marrow transduction/transplantation model where the conditional activation of the oncoprotein Myc expressed in the hematopoietic system could be assessed for influencing the host microenvironment. Constitutive ectopic expression...    »
 
Journal title abbreviation:
Oncotarget 
Year:
2015 
Journal volume:
Journal issue:
26 
Pages contribution:
21827-39 
Language:
eng 
TUM Institution:
III. Medizinische Klinik und Poliklinik