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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Nowald, Constantin; Penk, Anja; Chiu, Hsin-Yi; Bein, Thomas; Huster, Daniel; Lieleg, Oliver 
Titel:
A Selective Mucin/Methylcellulose Hybrid Gel with Tailored Mechanical Properties 
Abstract:
Mucin glycoproteins are key components of native mucus which serves as an initial barrier in the human body against microbial attack. Mucins are able to prevent bacterial adhesion and can trap viruses. However, the weak mechanical properties of mucin solutions have so far prevented their application in a physiological environment. Here, methylcellulose biopolymers are used as mechanical adjuvants to overcome this limitation and generate a thermoresponsive mucin/methylcellulose hybrid system. The...    »
 
Stichworte:
biopolymers; drug delivery systems; gelation; hydrogels; selectivity; MESOPOROUS SILICA NANOPARTICLES; PORCINE GASTRIC MUCIN; DRUG-DELIVERY; BACTERIAL ADHESION; LIGHT-SCATTERING; BARRIER; GELATION; HYDROGELS; MEMBRANE; DOXORUBICIN 
Dewey Dezimalklassifikation:
570 Biowissenschaften, Biologie 
Zeitschriftentitel:
Macromol. Biosci. 
Jahr:
2016 
Band / Volume:
16 
Jahr / Monat:
2016-04 
Seitenangaben Beitrag:
567-579 
Nachgewiesen in:
Web of Science 
Reviewed:
ja 
Sprache:
en 
Verlag / Institution:
Wiley-Blackwell 
Verlagsort:
Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 
Print-ISSN:
1616-5187 
E-ISSN:
1616-5195 
Publikationsdatum:
08.01.2016