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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Crouzier, Thomas; Boettcher, Kathrin; Geonnotti, Anthony R.; Kavanaugh, Nicole L.; Hirsch, Julie B.; Ribbeck, Katharina; Lieleg, Oliver 
Titel:
Modulating Mucin Hydration and Lubrication by Deglycosylation and Polyethylene Glycol Binding 
Abstract:
A key property of mucin glycoproteins is their exceptional capacity to hydrate and lubricate surfaces. In vivo, mucins assemble into mucus hydrogels that cover the epithelium and protect it from dehydration and shear stress. A better understanding of the origin of these properties could lead to new treatment strategies for patients with poor mucus coverage, defective mucus production, or glycosylation as caused by Sjogren syndrome, dry eye, or in the case of certain bacterial infections. In this...    »
 
Stichworte:
PORCINE GASTRIC MUCIN; BOUNDARY LUBRICATION; MOLECULAR-WEIGHT; SHEAR FORCES; SURFACES; POLYMER; MUCUS; POLYELECTROLYTE; GLYCOPROTEIN; SUBMAXILLARY 
Dewey Dezimalklassifikation:
500 Naturwissenschaften 
Zeitschriftentitel:
Adv. Mater. Interfaces 
Jahr:
2015 
Heft / Issue:
18 
Seitenangaben Beitrag:
n/a-n/a 
Nachgewiesen in:
Web of Science 
Reviewed:
ja 
Sprache:
en 
Verlag / Institution:
Wiley-Blackwell 
Print-ISSN:
2196-7350 
Publikationsdatum:
24.09.2015 
TUM Einrichtung:
Professur für Biomechanik 
Format:
Bild/Text