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Document type:
journal article 
Author(s):
Duffy, Michael J; McGowan, Patricia M; Harbeck, Nadia; Thomssen, Christoph; Schmitt, Manfred 
Title:
uPA and PAI-1 as biomarkers in breast cancer: validated for clinical use in level-of-evidence-1 studies. 
Abstract:
Urokinase plasminogen activator (uPA) is an extracellular matrix-degrading protease involved in cancer invasion and metastasis, interacting with plasminogen activator inhibitor-1 (PAI-1), which was originally identified as a blood-derived endogenous fast-acting inhibitor of uPA. At concentrations found in tumor tissue, however, both PAI-1 and uPA promote tumor progression and metastasis. Consistent with the causative role of uPA and PAI-1 in cancer dissemination, several retrospective and prospe...    »
 
Journal title abbreviation:
Breast Cancer Res 
Year:
2014 
Journal volume:
16 
Journal issue:
Pages contribution:
428 
Language:
eng 
Print-ISSN:
1465-5411 
TUM Institution:
Frauenklinik und Poliklinik