Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Sprinzl, MF; Russo, C; Kittner, J; Allgayer, S; Grambihler, A; Bartsch, B; Weinmann, A; Galle, PR; Schuchmann, M; Protzer, U; Bauer, T 
Titel:
Hepatitis B virus-specific T-cell responses during IFN administration in a small cohort of chronic hepatitis B patients under nucleos(t)ide analogue treatment. 
Abstract:
The effect of pegylated interferon-? (IFN) add-on therapy on HBV-specific T-cell responses was evaluated in 12 patients with stable, undetectable hepatitis B virus (HBV) load under nucleos(t)ide analogue therapy. Peripheral blood mononuclear cells were isolated at week 0, 4, 8, 12, 24 and 48 of IFN add-on therapy. Quantity and quality of circulating HBV S- and core-specific CD4 and CD8 T cells were analysed ex vivo by flow cytometry. HBV S- and core-specific CD4 T-cell numbers modestly increased...    »
 
Zeitschriftentitel:
J Viral Hepat 
Jahr:
2014 
Band / Volume:
21 
Heft / Issue:
Seitenangaben Beitrag:
633-41 
Sprache:
eng 
Print-ISSN:
1352-0504 
TUM Einrichtung:
Institut für Virologie