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Document type:
journal article 
Author(s):
Sprinzl, MF; Russo, C; Kittner, J; Allgayer, S; Grambihler, A; Bartsch, B; Weinmann, A; Galle, PR; Schuchmann, M; Protzer, U; Bauer, T 
Title:
Hepatitis B virus-specific T-cell responses during IFN administration in a small cohort of chronic hepatitis B patients under nucleos(t)ide analogue treatment. 
Abstract:
The effect of pegylated interferon-? (IFN) add-on therapy on HBV-specific T-cell responses was evaluated in 12 patients with stable, undetectable hepatitis B virus (HBV) load under nucleos(t)ide analogue therapy. Peripheral blood mononuclear cells were isolated at week 0, 4, 8, 12, 24 and 48 of IFN add-on therapy. Quantity and quality of circulating HBV S- and core-specific CD4 and CD8 T cells were analysed ex vivo by flow cytometry. HBV S- and core-specific CD4 T-cell numbers modestly increased...    »
 
Journal title abbreviation:
J Viral Hepat 
Year:
2014 
Journal volume:
21 
Journal issue:
Pages contribution:
633-41 
Language:
eng 
Print-ISSN:
1352-0504 
TUM Institution:
Institut für Virologie