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Dokumenttyp:
journal article 
Autor(en):
Bertero, Thomas; Lu, Yu; Annis, Sofia; Hale, Andrew; Bhat, Balkrishen; Saggar, Rajan; Saggar, Rajeev; Wallace, W Dean; Ross, David J; Vargas, Sara O; Graham, Brian B; Kumar, Rahul; Black, Stephen M; Fratz, Sohrab; Fineman, Jeffrey R; West, James D; Haley, Kathleen J; Waxman, Aaron B; Chau, B Nelson; Cottrill, Katherine A; Chan, Stephen Y 
Titel:
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. 
Abstract:
Development of the vascular disease pulmonary hypertension (PH) involves disparate molecular pathways that span multiple cell types. MicroRNAs (miRNAs) may coordinately regulate PH progression, but the integrative functions of miRNAs in this process have been challenging to define with conventional approaches. Here, analysis of the molecular network architecture specific to PH predicted that the miR-130/301 family is a master regulator of cellular proliferation in PH via regulation of subordinat...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2014 
Band / Volume:
124 
Heft / Issue:
Seitenangaben Beitrag:
3514-28 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler