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Document type:
journal article 
Author(s):
Rosemann, Michael; Gonzalez-Vasconcellos, Iria; Domke, Tanja; Kuosaite, Virginija; Schneider, Ralf; Kremer, Markus; Favor, Jack; Nathrath, Michaela; Atkinson, Michael J 
Title:
A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice. 
Abstract:
Syndromic forms of osteosarcoma (OS) account for less than 10% of all recorded cases of this malignancy. An individual OS predisposition is also possible by the inheritance of low penetrance alleles of tumor susceptibility genes, usually without evidence of a syndromic condition. Genetic variants involved in such a non-syndromic form of tumor predisposition are difficult to identify, given the low incidence of osteosarcoma cases and the genetic heterogeneity of patients. We recently mapped a maj...    »
 
Journal title abbreviation:
Mol Cancer 
Year:
2014 
Journal volume:
13 
Pages contribution:
182 
Language:
eng 
TUM Institution:
Kinderklinik und Poliklinik