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Document type:
journal article 
Author(s):
Gómez Damián, Pedro A; Sperl, Jonathan I; Janich, Martin A; Khegai, Oleksandr; Wiesinger, Florian; Glaser, Steffen J; Haase, Axel; Schwaiger, Markus; Schulte, Rolf F; Menzel, Marion I 
Title:
Multisite Kinetic Modeling of (13)C Metabolic MR Using [1-(13)C]Pyruvate. 
Abstract:
Hyperpolarized (13)C imaging allows real-time in vivo measurements of metabolite levels. Quantification of metabolite conversion between [1-(13)C]pyruvate and downstream metabolites [1-(13)C]alanine, [1-(13)C]lactate, and [(13)C]bicarbonate can be achieved through kinetic modeling. Since pyruvate interacts dynamically and simultaneously with its downstream metabolites, the purpose of this work is the determination of parameter values through a multisite, dynamic model involving possible biochemi...    »
 
Journal title abbreviation:
Radiol Res Pract 
Year:
2014 
Journal volume:
2014 
Pages contribution:
871619 
Language:
eng 
Print-ISSN:
2090-1941 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik