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Document type:
journal article 
Author(s):
Bhadury, Joydeep; Nilsson, Lisa M; Muralidharan, Somsundar Veppil; Green, Lydia C; Li, Zhoulei; Gesner, Emily M; Hansen, Henrik C; Keller, Ulrich B; McLure, Kevin G; Nilsson, Jonas A 
Title:
BET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphoma. 
Abstract:
The bromodomain and extraterminal (BET) domain family of proteins binds to acetylated lysines on histones and regulates gene transcription. Recently, BET inhibitors (BETi) have been developed that show promise as potent anticancer drugs against various solid and hematological malignancies. Here we show that the structurally novel and orally bioavailable BET inhibitor RVX2135 inhibits proliferation and induces apoptosis of lymphoma cells arising in Myc-transgenic mice in vitro and in vivo. We fin...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2014 
Journal volume:
111 
Journal issue:
26 
Pages contribution:
E2721-30 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
III. Medizinische Klinik und Poliklinik