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Dokumenttyp:
journal article 
Autor(en):
Ehmer, Ursula; Zmoos, Anne-Flore; Auerbach, Raymond K; Vaka, Dedeepya; Butte, Atul J; Kay, Mark A; Sage, Julien 
Titel:
Organ size control is dominant over Rb family inactivation to restrict proliferation in vivo. 
Abstract:
In mammals, a cell's decision to divide is thought to be under the control of the Rb/E2F pathway. We previously found that inactivation of the Rb family of cell cycle inhibitors (Rb, p107, and p130) in quiescent liver progenitors leads to uncontrolled division and cancer initiation. Here, we show that, in contrast, deletion of the entire Rb gene family in mature hepatocytes is not sufficient for their long-term proliferation. The cell cycle block in Rb family mutant hepatocytes is independent of...    »
 
Zeitschriftentitel:
Cell Rep 
Jahr:
2014 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
371-81 
Sprache:
eng 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik