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Document type:
journal article 
Author(s):
Ritter, M; Straubinger, K; Schmidt, S; Busch, D H; Hagner, S; Garn, H; Prazeres da Costa, C; Layland, L E 
Title:
Functional relevance of NLRP3 inflammasome-mediated interleukin (IL)-1? during acute allergic airway inflammation. 
Abstract:
Overall asthmatic symptoms can be controlled with diverse therapeutic agents. However, certain symptomatic individuals remain at risk for serious morbidity and mortality, which prompts the identification of novel therapeutic targets and treatment strategies. Thus, using an adjuvant-free T helper type 2 (Th2) murine model, we have deciphered the role of interleukin (IL)-1 signalling during allergic airway inflammation (AAI). Because functional IL-1? depends on inflammasome activation we first stu...    »
 
Journal title abbreviation:
Clin Exp Immunol 
Year:
2014 
Journal volume:
178 
Journal issue:
Pages contribution:
212-23 
Language:
eng 
Print-ISSN:
0009-9104 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene