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Document type:
journal article 
Author(s):
Odendahl, Marcus; Grigoleit, G Ulrich; Bönig, Halvard; Neuenhahn, Michael; Albrecht, Julia; Anderl, Florian; Germeroth, Lothar; Schmitz, Marc; Bornhäuser, Martin; Einsele, Hermann; Seifried, Erhard; Busch, Dirk H; Tonn, Torsten 
Title:
Clinical-scale isolation of'minimally manipulated' cytomegalovirus-specific donor lymphocytes for the treatment of refractory cytomegalovirus disease. 
Abstract:
Reactivation of cytomegalovirus (CMV) after hematopoietic stem cell transplantation remains a major cause of morbidity despite improved antiviral drug therapies. Selective restoration of CMV immunity by adoptive transfer of CMV-specific T cells is the only alternative approach that has been shown to be effective and non-toxic. We describe the results of clinical-scale isolations of CMV-specific donor lymphocytes with the use of a major histocompatibility (MHC) class I peptide streptamer-based is...    »
 
Journal title abbreviation:
Cytotherapy 
Year:
2014 
Journal volume:
16 
Journal issue:
Pages contribution:
1245-56 
Language:
eng 
Print-ISSN:
1465-3249 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene