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Document type:
journal article 
Author(s):
Graef, Patricia; Buchholz, Veit R; Stemberger, Christian; Flossdorf, Michael; Henkel, Lynette; Schiemann, Matthias; Drexler, Ingo; Höfer, Thomas; Riddell, Stanley R; Busch, Dirk H 
Title:
Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8(+) central memory T cells. 
Abstract:
Maintenance of immunological memory has been proposed to rely on stem-cell-like lymphocytes. However, data supporting this hypothesis are focused on the developmental potential of lymphocyte populations and are thus insufficient to establish the functional hallmarks of stemness. Here, we investigated self-renewal capacity and multipotency of individual memory lymphocytes by in vivo fate mapping of CD8(+) T cells and their descendants across three generations of serial single-cell adoptive transf...    »
 
Journal title abbreviation:
Immunity 
Year:
2014 
Journal volume:
41 
Journal issue:
Pages contribution:
116-26 
Language:
eng 
Print-ISSN:
1074-7613 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene