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Dokumenttyp:
journal article 
Autor(en):
Andersson, Robin; Gebhard, Claudia; Miguel-Escalada, Irene; Hoof, Ilka; Bornholdt, Jette; Boyd, Mette; Chen, Yun; Zhao, Xiaobei; Schmidl, Christian; Suzuki, Takahiro; Ntini, Evgenia; Arner, Erik; Valen, Eivind; Li, Kang; Schwarzfischer, Lucia; Glatz, Dagmar; Raithel, Johanna; Lilje, Berit; Rapin, Nicolas; Bagger, Frederik Otzen; Jørgensen, Mette; Andersen, Peter Refsing; Bertin, Nicolas; Rackham, Owen; Burroughs, A Maxwell; Baillie, J Kenneth; Ishizu, Yuri; Shimizu, Yuri; Furuhata, Erina; Maeda,...    »
 
Titel:
An atlas of active enhancers across human cell types and tissues. 
Abstract:
Enhancers control the correct temporal and cell-type-specific activation of gene expression in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial to understand the regulation of differentiation and homeostasis. Here we use the FANTOM5 panel of samples, covering the majority of human tissues and cell types, to produce an atlas of active, in vivo-transcribed enhancers. We show that enhancers share properties with CpG-poor messenger RNA promoters but prod...    »
 
Zeitschriftentitel:
Nature 
Jahr:
2014 
Band / Volume:
507 
Heft / Issue:
7493 
Seitenangaben Beitrag:
455-61 
Sprache:
eng 
Print-ISSN:
0028-0836 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene