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Dokumenttyp:
journal article 
Autor(en):
Wood, Andrew R; Esko, Tonu; Yang, Jian; Vedantam, Sailaja; Pers, Tune H; Gustafsson, Stefan; Chu, Audrey Y; Estrada, Karol; Luan, Jian'an; Kutalik, Zoltán; Amin, Najaf; Buchkovich, Martin L; Croteau-Chonka, Damien C; Day, Felix R; Duan, Yanan; Fall, Tove; Fehrmann, Rudolf; Ferreira, Teresa; Jackson, Anne U; Karjalainen, Juha; Lo, Ken Sin; Locke, Adam E; Mägi, Reedik; Mihailov, Evelin; Porcu, Eleonora; Randall, Joshua C; Scherag, André; Vinkhuyzen, Anna A E; Westra, Harm-Jan; Winkler, Thomas W; W...    »
 
Titel:
Defining the role of common variation in the genomic and biological architecture of adult human height. 
Abstract:
Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ~2,000, ~3,700 and ~9,500 SNPs explained ~21%, ~24% and ~29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for gen...    »
 
Zeitschriftentitel:
Nat Genet 
Jahr:
2014 
Band / Volume:
46 
Heft / Issue:
11 
Seitenangaben Beitrag:
1173-86 
Sprache:
eng 
Print-ISSN:
1061-4036 
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen; Institut für Humangenetik