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Dokumenttyp:
journal article 
Autor(en):
Schramm, Katharina; Marzi, Carola; Schurmann, Claudia; Carstensen, Maren; Reinmaa, Eva; Biffar, Reiner; Eckstein, Gertrud; Gieger, Christian; Grabe, Hans-Jörgen; Homuth, Georg; Kastenmüller, Gabriele; Mägi, Reedik; Metspalu, Andres; Mihailov, Evelin; Peters, Annette; Petersmann, Astrid; Roden, Michael; Strauch, Konstantin; Suhre, Karsten; Teumer, Alexander; Völker, Uwe; Völzke, Henry; Wang-Sattler, Rui; Waldenberger, Melanie; Meitinger, Thomas; Illig, Thomas; Herder, Christian; Grallert, Harald;...    »
 
Titel:
Mapping the genetic architecture of gene regulation in whole blood. 
Abstract:
We aimed to assess whether whole blood expression quantitative trait loci (eQTLs) with effects in cis and trans are robust and can be used to identify regulatory pathways affecting disease susceptibility.We performed whole-genome eQTL analyses in 890 participants of the KORA F4 study and in two independent replication samples (SHIP-TREND, N = 976 and EGCUT, N = 842) using linear regression models and Bonferroni correction.In the KORA F4 study, 4,116 cis-eQTLs (defined as SNP-probe pairs where th...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2014 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e93844 
Sprache:
eng 
TUM Einrichtung:
Institut für Humangenetik