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Dokumenttyp:
journal article 
Autor(en):
Geismann, C; Grohmann, F; Sebens, S; Wirths, G; Dreher, A; Häsler, R; Rosenstiel, P; Hauser, C; Egberts, J-H; Trauzold, A; Schneider, G; Sipos, B; Zeissig, S; Schreiber, S; Schäfer, H; Arlt, A 
Titel:
c-Rel is a critical mediator of NF-?B-dependent TRAIL resistance of pancreatic cancer cells. 
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest malignancies with an overall life expectancy of 6 months despite current therapies. NF-?B signalling has been shown to be critical for this profound cell-autonomous resistance against chemotherapeutic drugs and death receptor-induced apoptosis, but little is known about the role of the c-Rel subunit in solid cancer and PDAC apoptosis control. In the present study, by analysis of genome-wide patterns of c-Rel-dependent gene e...    »
 
Zeitschriftentitel:
Cell Death Dis 
Jahr:
2014 
Band / Volume:
Seitenangaben Beitrag:
e1455 
Sprache:
eng 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik