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Document type:
journal article 
Author(s):
Zhao, Chun-Mei; Hayakawa, Yoku; Kodama, Yosuke; Muthupalani, Sureshkumar; Westphalen, Christoph B; Andersen, Gøran T; Flatberg, Arnar; Johannessen, Helene; Friedman, Richard A; Renz, Bernhard W; Sandvik, Arne K; Beisvag, Vidar; Tomita, Hiroyuki; Hara, Akira; Quante, Michael; Li, Zhishan; Gershon, Michael D; Kaneko, Kazuhiro; Fox, James G; Wang, Timothy C; Chen, Duan 
Title:
Denervation suppresses gastric tumorigenesis. 
Abstract:
The nervous system plays an important role in the regulation of epithelial homeostasis and has also been postulated to play a role in tumorigenesis. We provide evidence that proper innervation is critical at all stages of gastric tumorigenesis. In three separate mouse models of gastric cancer, surgical or pharmacological denervation of the stomach (bilateral or unilateral truncal vagotomy, or local injection of botulinum toxin type A) markedly reduced tumor incidence and progression, but only in...    »
 
Journal title abbreviation:
Sci Transl Med 
Year:
2014 
Journal volume:
Journal issue:
250 
Pages contribution:
250ra115 
Language:
eng 
Print-ISSN:
1946-6234 
TUM Institution:
II. Medizinische Klinik und Poliklinik