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Dokumenttyp:
journal article 
Autor(en):
Zhao, Chun-Mei; Hayakawa, Yoku; Kodama, Yosuke; Muthupalani, Sureshkumar; Westphalen, Christoph B; Andersen, Gøran T; Flatberg, Arnar; Johannessen, Helene; Friedman, Richard A; Renz, Bernhard W; Sandvik, Arne K; Beisvag, Vidar; Tomita, Hiroyuki; Hara, Akira; Quante, Michael; Li, Zhishan; Gershon, Michael D; Kaneko, Kazuhiro; Fox, James G; Wang, Timothy C; Chen, Duan 
Titel:
Denervation suppresses gastric tumorigenesis. 
Abstract:
The nervous system plays an important role in the regulation of epithelial homeostasis and has also been postulated to play a role in tumorigenesis. We provide evidence that proper innervation is critical at all stages of gastric tumorigenesis. In three separate mouse models of gastric cancer, surgical or pharmacological denervation of the stomach (bilateral or unilateral truncal vagotomy, or local injection of botulinum toxin type A) markedly reduced tumor incidence and progression, but only in...    »
 
Zeitschriftentitel:
Sci Transl Med 
Jahr:
2014 
Band / Volume:
Heft / Issue:
250 
Seitenangaben Beitrag:
250ra115 
Sprache:
eng 
Print-ISSN:
1946-6234 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik