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Document type:
journal article 
Author(s):
Li, D; Beisswenger, C; Herr, C; Hellberg, J; Han, G; Zakharkina, T; Voss, M; Wiewrodt, R; Bohle, R M; Menger, M D; Schmid, R M; Stöckel, D; Lenhof, H-P; Bals, R 
Title:
Myeloid cell RelA/p65 promotes lung cancer proliferation through Wnt/?-catenin signaling in murine and human tumor cells. 
Abstract:
Smoking is the most important risk factor for both lung cancer (LC) and chronic obstructive pulmonary disease. The aim of this study was to investigate the role of myeloid cell nuclear factor-?B in the regulation of tumor cell growth signaling. We subjected mice lacking myeloid RelA/p65 (rela(?-/-)) to a metastatic LC model. Cigarette smoke (CS) exposure significantly increased the proliferation of Lewis lung carcinoma cell tumors in wild-type mice. In CS-exposed rela(?-/-) mice, the tumor growt...    »
 
Journal title abbreviation:
Oncogene 
Year:
2014 
Journal volume:
33 
Journal issue:
10 
Pages contribution:
1239-48 
Language:
eng 
Print-ISSN:
0950-9232 
TUM Institution:
II. Medizinische Klinik und Poliklinik