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Dokumenttyp:
journal article 
Autor(en):
Schönhuber, Nina; Seidler, Barbara; Schuck, Kathleen; Veltkamp, Christian; Schachtler, Christina; Zukowska, Magdalena; Eser, Stefan; Feyerabend, Thorsten B; Paul, Mariel C; Eser, Philipp; Klein, Sabine; Lowy, Andrew M; Banerjee, Ruby; Yang, Fangtang; Lee, Chang-Lung; Moding, Everett J; Kirsch, David G; Scheideler, Angelika; Alessi, Dario R; Varela, Ignacio; Bradley, Allan; Kind, Alexander; Schnieke, Angelika E; Rodewald, Hans-Reimer; Rad, Roland; Schmid, Roland M; Schneider, Günter; Saur, Dieter 
Titel:
A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. 
Abstract:
Genetically engineered mouse models (GEMMs) have dramatically improved our understanding of tumor evolution and therapeutic resistance. However, sequential genetic manipulation of gene expression and targeting of the host is almost impossible using conventional Cre-loxP-based models. We have developed an inducible dual-recombinase system by combining flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies to improve GEMMs of pancreatic cancer. This enables investigation of multistep carci...    »
 
Zeitschriftentitel:
Nat Med 
Jahr:
2014 
Band / Volume:
20 
Heft / Issue:
11 
Seitenangaben Beitrag:
1340-7 
Sprache:
eng 
Print-ISSN:
1078-8956 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik