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Dokumenttyp:
journal article 
Autor(en):
Heck, Angela; Fastenrath, Matthias; Ackermann, Sandra; Auschra, Bianca; Bickel, Horst; Coynel, David; Gschwind, Leo; Jessen, Frank; Kaduszkiewicz, Hanna; Maier, Wolfgang; Milnik, Annette; Pentzek, Michael; Riedel-Heller, Steffi G; Ripke, Stephan; Spalek, Klara; Sullivan, Patrick; Vogler, Christian; Wagner, Michael; Weyerer, Siegfried; Wolfsgruber, Steffen; de Quervain, Dominique J-F; Papassotiropoulos, Andreas 
Titel:
Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity. 
Abstract:
Working memory, the capacity of actively maintaining task-relevant information during a cognitive task, is a heritable trait. Working memory deficits are characteristic for many psychiatric disorders. We performed genome-wide gene set enrichment analyses in multiple independent data sets of young and aged cognitively healthy subjects (n = 2,824) and in a large schizophrenia case-control sample (n = 32,143). The voltage-gated cation channel activity gene set, consisting of genes related to neuron...    »
 
Zeitschriftentitel:
Neuron 
Jahr:
2014 
Band / Volume:
81 
Heft / Issue:
Seitenangaben Beitrag:
1203-13 
Sprache:
eng 
Print-ISSN:
0896-6273 
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie