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Document type:
journal article 
Author(s):
Dudel, Josef 
Title:
?-Conotoxin M1 (CTx) blocks ?? binding sites of adult nicotinic receptors while ACh binding at ?? sites elicits only small and short quantal synaptic currents. 
Abstract:
In'embryonic' nicotinic receptors, low CTx concentrations are known to block only the ?? binding site, whereas binding of ACh at the ??-site elicits short single channel openings and short bursts. In adult muscles the ??- is replaced by the ??-site. Quantal EPSCs (qEPSCs) were elicited in adult muscles by depolarization pulses and recorded through a perfused macropatch electrode. One to 200 nmol L(-1) CTx reduced amplitudes and decay time constants of qEPSCs, but increased their rise times. CTx...    »
 
Journal title abbreviation:
Physiol Rep 
Year:
2014 
Journal volume:
Journal issue:
12 
Language:
eng 
TUM Institution:
Institut für Neurowissenschaften