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Document type:
journal article 
Author(s):
Perneczky, Robert; Alexopoulos, Panagiotis; Alzheimer's Disease euroimaging Initiative 
Title:
Cerebrospinal fluid BACE1 activity and markers of amyloid precursor protein metabolism and axonal degeneration in Alzheimer's disease. 
Abstract:
The objective of this study was to assess cerebrospinal fluid (CSF) ?-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) activity in relation to Alzheimer's disease (AD) and to correlate the enzyme activity with protein markers of APP metabolism and axonal degeneration.BACE1 activity and protein concentrations were measured and analyzed in 342 participants of the Alzheimer's Disease Neuroimaging Initiative, including 99 normal control, 75 stable mild cognitive impairment (MCI), 87 pr...    »
 
Journal title abbreviation:
Alzheimers Dement 
Year:
2014 
Journal volume:
10 
Journal issue:
5 Suppl 
Pages contribution:
S425-S429.e1 
Language:
eng 
Print-ISSN:
1552-5260 
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie