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Document type:
journal article 
Author(s):
Reichel, Martin; Richter-Schmidinger, Tanja; Mühle, Christiane; Rhein, Cosima; Alexopoulos, Panagiotis; Schwab, Sibylle G; Gulbins, Erich; Kornhuber, Johannes 
Title:
The common acid sphingomyelinase polymorphism p.G508R is associated with self-reported allergy. 
Abstract:
Acid sphingomyelinase (ASM) is a key regulator of ceramide-dependent signalling pathways. Among others, activation of ASM can be induced by CD95 or cytokine signalling and by cellular stress resulting from inflammation or infection. Increased ASM activity was observed in a variety of human diseases including inflammatory and neuropsychiatric disorders. We hypothesized that basal ASM activity might influence the susceptibility for common human diseases.The general health condition of 100 young pe...    »
 
Journal title abbreviation:
Cell Physiol Biochem 
Year:
2014 
Journal volume:
34 
Journal issue:
Pages contribution:
82-91 
Language:
eng 
Print-ISSN:
1015-8987 
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie