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Document type:
journal article 
Author(s):
Busse, Kathy; Strotmann, Rainer; Strecker, Karl; Wegner, Florian; Devanathan, Vasudharani; Gohla, Antje; Schöneberg, Torsten; Schwarz, Johannes 
Title:
Adaptive gene regulation in the Striatum of RGS9-deficient mice. 
Abstract:
RGS9-deficient mice show drug-induced dyskinesia but normal locomotor activity under unchallenged conditions.Genes related to Ca2+ signaling and their functions were regulated in RGS9-deficient mice.Changes in Ca2+ signaling that compensate for RGS9 loss-of-function can explain the normal locomotor activity in RGS9-deficient mice under unchallenged conditions.Identified signaling components may represent novel targets in antidyskinetic therapy. The long splice variant of the regulator of G-prote...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2014 
Journal volume:
Journal issue:
Pages contribution:
e92605 
Language:
eng 
TUM Institution:
Neurologische Klinik und Poliklinik