Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Busse, Kathy; Strotmann, Rainer; Strecker, Karl; Wegner, Florian; Devanathan, Vasudharani; Gohla, Antje; Schöneberg, Torsten; Schwarz, Johannes 
Titel:
Adaptive gene regulation in the Striatum of RGS9-deficient mice. 
Abstract:
RGS9-deficient mice show drug-induced dyskinesia but normal locomotor activity under unchallenged conditions.Genes related to Ca2+ signaling and their functions were regulated in RGS9-deficient mice.Changes in Ca2+ signaling that compensate for RGS9 loss-of-function can explain the normal locomotor activity in RGS9-deficient mice under unchallenged conditions.Identified signaling components may represent novel targets in antidyskinetic therapy. The long splice variant of the regulator of G-prote...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2014 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e92605 
Sprache:
eng 
TUM Einrichtung:
Neurologische Klinik und Poliklinik