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Dokumenttyp:
journal article 
Autor(en):
Xu, Hong; Rösler, Thomas W; Carlsson, Thomas; de Andrade, Anderson; Fiala, Ondrej; Hollerhage, Matthias; Oertel, Wolfgang H; Goedert, Michel; Aigner, Achim; Höglinger, Gunter U 
Titel:
Tau silencing by siRNA in the P301S mouse model of tauopathy. 
Abstract:
Suppression of tau protein expression has been shown to improve behavioral deficits in mouse models of tauopathies, offering an attractive therapeutic approach. Experimentally this had been achieved by switching off the promoters controlling the transgenic human tau gene (MAPT), which is not possible in human patients. The aim of the present study was therefore to evaluate the effectiveness of small interfering RNAs (siRNAs) and their cerebral delivery to suppress human tau expression in vivo, w...    »
 
Zeitschriftentitel:
Curr Gene Ther 
Jahr:
2014 
Band / Volume:
14 
Heft / Issue:
Seitenangaben Beitrag:
343-51 
Sprache:
eng 
Print-ISSN:
1566-5232 
TUM Einrichtung:
Neurologische Klinik und Poliklinik