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Document type:
journal article 
Author(s):
Xu, Hong; Rösler, Thomas W; Carlsson, Thomas; de Andrade, Anderson; Fiala, Ondrej; Hollerhage, Matthias; Oertel, Wolfgang H; Goedert, Michel; Aigner, Achim; Höglinger, Gunter U 
Title:
Tau silencing by siRNA in the P301S mouse model of tauopathy. 
Abstract:
Suppression of tau protein expression has been shown to improve behavioral deficits in mouse models of tauopathies, offering an attractive therapeutic approach. Experimentally this had been achieved by switching off the promoters controlling the transgenic human tau gene (MAPT), which is not possible in human patients. The aim of the present study was therefore to evaluate the effectiveness of small interfering RNAs (siRNAs) and their cerebral delivery to suppress human tau expression in vivo, w...    »
 
Journal title abbreviation:
Curr Gene Ther 
Year:
2014 
Journal volume:
14 
Journal issue:
Pages contribution:
343-51 
Language:
eng 
Print-ISSN:
1566-5232 
TUM Institution:
Neurologische Klinik und Poliklinik