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Document type:
journal article 
Author(s):
Vahl, J Christoph; Drees, Christoph; Heger, Klaus; Heink, Sylvia; Fischer, Julius C; Nedjic, Jelena; Ohkura, Naganari; Morikawa, Hiromasa; Poeck, Hendrik; Schallenberg, Sonja; Rieß, David; Hein, Marco Y; Buch, Thorsten; Polic, Bojan; Schönle, Anne; Zeiser, Robert; Schmitt-Gräff, Annette; Kretschmer, Karsten; Klein, Ludger; Korn, Thomas; Sakaguchi, Shimon; Schmidt-Supprian, Marc 
Title:
Continuous T cell receptor signals maintain a functional regulatory T cell pool. 
Abstract:
Regulatory T (Treg) cells maintain immune homeostasis and prevent inflammatory and autoimmune responses. During development, thymocytes bearing a moderately self-reactive T cell receptor (TCR) can be selected to become Treg cells. Several observations suggest that also in the periphery mature Treg cells continuously receive self-reactive TCR signals. However, the importance of this inherent autoreactivity for Treg cell biology remains poorly defined. To address this open question, we genetically...    »
 
Journal title abbreviation:
Immunity 
Year:
2014 
Journal volume:
41 
Journal issue:
Pages contribution:
722-36 
Language:
eng 
Print-ISSN:
1074-7613 
TUM Institution:
III. Medizinische Klinik und Poliklinik; Neurologische Klinik und Poliklinik; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene