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Document type:
journal article 
Author(s):
Patrucco, Enrico; Domes, Katrin; Sbroggió, Mauro; Blaich, Anne; Schlossmann, Jens; Desch, Matthias; Rybalkin, Sergei D; Beavo, Joseph A; Lukowski, Robert; Hofmann, Franz 
Title:
Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis. 
Abstract:
Conflicting results have been reported for the roles of cGMP and cGMP-dependent protein kinase I (cGKI) in various pathological conditions leading to cardiac hypertrophy and fibrosis. A cardioprotective effect of cGMP/cGKI has been reported in whole animals and isolated cardiomyocytes, but recent evidence from a mouse model expressing cGKI? only in smooth muscle (?RM) but not in cardiomyocytes, endothelial cells, or fibroblasts has forced a reevaluation of the requirement for cGKI activity in th...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
2014 
Journal volume:
111 
Journal issue:
35 
Pages contribution:
12925-9 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
Institut für Pharmakologie und Toxikologie