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Document type:
journal article 
Author(s):
Ahles, Andrea; Engelhardt, Stefan 
Title:
Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease. 
Abstract:
The human genome encodes nine different adrenoceptor genes. These are grouped into three families, namely, the ?1-, ?2-, and ?-adrenoceptors, with three family members each. Adrenoceptors are expressed by most cell types of the human body and are primary targets of the catecholamines epinephrine and norepinephrine that are released from the sympathetic nervous system during its activation. Upon catecholamine binding, adrenoceptors change conformation, couple to and activate G proteins, and there...    »
 
Journal title abbreviation:
Pharmacol Rev 
Year:
2014 
Journal volume:
66 
Journal issue:
Pages contribution:
598-637 
Language:
eng 
Print-ISSN:
0031-6997 
TUM Institution:
Institut für Pharmakologie und Toxikologie