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Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
Author(s):
Scheufele, Florian; Wolf, Benjamin; Kruse, Michael; Hartmann, Thomas; Lempart, Justine; Muehlich, Susanne; Pfeiffer, Andreas F H; Field, Loren J; Charron, Maureen J; Pan, Zhen-Qiang; Engelhardt, Stefan; Sarikas, Antonio 
Title:
Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling. 
Abstract:
Dysfunctional regulation of signaling pathways downstream of the insulin receptor plays a pivotal role in the pathogenesis of insulin resistance and type 2 diabetes. In this study we report both in vitro and in vivo experimental evidence for a role of Cullin-RING E3 ubiquitin ligase 7 (CRL7) in the regulation of insulin signaling and glucose homeostasis. We show that Cul7(-/-) mouse embryonic fibroblasts displayed enhanced AKT and Erk MAP kinase phosphorylation upon insulin stimulation. Depletio...    »
 
Journal title abbreviation:
Cell Signal 
Year:
2014 
Journal volume:
26 
Journal issue:
Pages contribution:
233-9 
Language:
eng 
Print-ISSN:
0898-6568 
TUM Institution:
Institut für Pharmakologie und Toxikologie