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Document type:
journal article 
Author(s):
Wang, R; Kwon, I-K; Singh, N; Islam, B; Liu, K; Sridhar, S; Hofmann, F; Browning, D D 
Title:
Type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium. 
Abstract:
Analysis of knockout animals indicates that 3',5'cyclic guanosine monophosphate (cGMP) has an important role in gut homeostasis but the signaling mechanism is not known. The goals of this study were to test whether increasing cGMP could affect colon homeostasis and determine the mechanism. We increased cGMP in the gut of Prkg2(+/+) and Prkg2(-/-) mice by treating with the PDE5 inhibitor Vardenafil (IP). Proliferation, differentiation and apoptosis in the colon mucosa were then quantitated. Varde...    »
 
Journal title abbreviation:
Cell Death Differ 
Year:
2014 
Journal volume:
21 
Journal issue:
Pages contribution:
427-37 
Language:
eng 
Print-ISSN:
1350-9047 
TUM Institution:
Institut für Pharmakologie und Toxikologie