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Dokumenttyp:
journal article 
Autor(en):
Werfel, Stanislas; Jungmann, Andreas; Lehmann, Lorenz; Ksienzyk, Jan; Bekeredjian, Raffi; Kaya, Ziya; Leuchs, Barbara; Nordheim, Alfred; Backs, Johannes; Engelhardt, Stefan; Katus, Hugo A; Müller, Oliver J 
Titel:
Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase. 
Abstract:
Inducible gene targeting in mice using the Cre/LoxP system has become a valuable tool to analyse the roles of specific genes in the adult heart. However, the commonly used Myh6-MerCreMer system requires time-consuming breeding schedules and is potentially associated with cardiac side effects, which may result in transient cardiac dysfunction. The aim of our study was to establish a rapid and simple system for cardiac gene inactivation in conditional knockout mice by gene transfer of a Cre recomb...    »
 
Zeitschriftentitel:
Cardiovasc Res 
Jahr:
2014 
Band / Volume:
104 
Heft / Issue:
Seitenangaben Beitrag:
15-23 
Sprache:
eng 
Print-ISSN:
0008-6363 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie