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Dokumenttyp:
journal article 
Autor(en):
Friedrich, Felix W; Reischmann, Silke; Schwalm, Aileen; Unger, Andreas; Ramanujam, Deepak; Münch, Julia; Müller, Oliver J; Hengstenberg, Christian; Galve, Enrique; Charron, Philippe; Linke, Wolfgang A; Engelhardt, Stefan; Patten, Monica; Richard, Pascale; van der Velden, Jolanda; Eschenhagen, Thomas; Isnard, Richard; Carrier, Lucie 
Titel:
FHL2 expression and variants in hypertrophic cardiomyopathy. 
Abstract:
Based on evidence that FHL2 (four and a half LIM domains protein 2) negatively regulates cardiac hypertrophy we tested whether FHL2 altered expression or variants could be associated with hypertrophic cardiomyopathy (HCM). HCM is a myocardial disease characterized by left ventricular hypertrophy, diastolic dysfunction and increased interstitial fibrosis and is mainly caused by mutations in genes coding for sarcomeric proteins. FHL2 mRNA level, FHL2 protein level and I-band-binding density were l...    »
 
Zeitschriftentitel:
Basic Res Cardiol 
Jahr:
2014 
Band / Volume:
109 
Heft / Issue:
Seitenangaben Beitrag:
451 
Sprache:
eng 
Print-ISSN:
0300-8428 
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie; Klinik für Herz- und Kreislauferkrankungen