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Document type:
journal article 
Author(s):
Friedrich, Felix W; Reischmann, Silke; Schwalm, Aileen; Unger, Andreas; Ramanujam, Deepak; Münch, Julia; Müller, Oliver J; Hengstenberg, Christian; Galve, Enrique; Charron, Philippe; Linke, Wolfgang A; Engelhardt, Stefan; Patten, Monica; Richard, Pascale; van der Velden, Jolanda; Eschenhagen, Thomas; Isnard, Richard; Carrier, Lucie 
Title:
FHL2 expression and variants in hypertrophic cardiomyopathy. 
Abstract:
Based on evidence that FHL2 (four and a half LIM domains protein 2) negatively regulates cardiac hypertrophy we tested whether FHL2 altered expression or variants could be associated with hypertrophic cardiomyopathy (HCM). HCM is a myocardial disease characterized by left ventricular hypertrophy, diastolic dysfunction and increased interstitial fibrosis and is mainly caused by mutations in genes coding for sarcomeric proteins. FHL2 mRNA level, FHL2 protein level and I-band-binding density were l...    »
 
Journal title abbreviation:
Basic Res Cardiol 
Year:
2014 
Journal volume:
109 
Journal issue:
Pages contribution:
451 
Language:
eng 
Print-ISSN:
0300-8428 
TUM Institution:
Institut für Pharmakologie und Toxikologie; Klinik für Herz- und Kreislauferkrankungen