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Document type:
journal article 
Author(s):
Gorka, Oliver; Wanninger, Stefan; Ruland, Jürgen 
Title:
Detection of NF-?B pathway activation in T helper cells. 
Abstract:
Upon activation of CD4+ T helper cells the transcription factor complex NF-?B becomes activated and its subunits are able to translocate to the nucleus. There, the dimerized proteins regulate the transcription of for example cytokine and pro-survival genes. This process is of central importance for a proper function of T helper cells as its loss causes severe immunodeficiency, whereas its deregulation can contribute to lymphomagenesis or autoimmunity. In this protocol we describe four methods to...    »
 
Journal title abbreviation:
Methods Mol Biol 
Year:
2014 
Journal volume:
1193 
Pages contribution:
69-83 
Language:
eng 
Print-ISSN:
1064-3745 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie