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Dokumenttyp:
journal article 
Autor(en):
Markó, Lajos; Henke, Norbert; Park, Joon-Keun; Spallek, Bastian; Qadri, Fatimunnisa; Balogh, András; Apel, Ingrid J; Oravecz-Wilson, Katherine I; Choi, Mira; Przybyl, Lukasz; Binger, Katrina J; Haase, Nadine; Wilck, Nicola; Heuser, Arnd; Fokuhl, Verena; Ruland, Jürgen; Lucas, Peter C; McAllister-Lucas, Linda M; Luft, Friedrich C; Dechend, Ralf; Müller, Dominik N 
Titel:
Bcl10 mediates angiotensin II-induced cardiac damage and electrical remodeling. 
Abstract:
Angiotensin (Ang) II is a potent mediator of both hypertension and cardiac damage; however, the mechanisms by which this occur remain unclear. B-cell lymphoma/leukemia 10 (Bcl10) is a member of the CBM signalosome, which links Ang II and nuclear factor-?B signaling. We hypothesized that Bcl10 is pivotal in the pathogenesis of Ang II-induced cardiac damage. Ang II infusion in mice lacking Bcl10 resulted in reduced cardiac fibrosis, less cellular infiltration, and improved arrhythmogenic electric...    »
 
Zeitschriftentitel:
Hypertension 
Jahr:
2014 
Band / Volume:
64 
Heft / Issue:
Seitenangaben Beitrag:
1032-9 
Sprache:
eng 
Print-ISSN:
0194-911X 
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie