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Dokumenttyp:
journal article 
Autor(en):
Pasquini, Lorenzo; Tonch, Annika; Plant, Claudia; Zherdin, Andrew; Ortner, Marion; Kurz, Alexander; Förstl, Hans; Zimmer, Claus; Grimmer, Timo; Wohlschäger, Afra; Riedl, Valentin; Sorg, Christian 
Titel:
Intrinsic brain activity of cognitively normal older persons resembles more that of patients both with and at risk for Alzheimer's disease than that of healthy younger persons. 
Abstract:
In Alzheimer's disease (AD), recent findings suggest that amyloid-? (A?)-pathology might start 20-30 years before first cognitive symptoms arise. To account for age as most relevant risk factor for sporadic AD, it has been hypothesized that lifespan intrinsic (i.e., ongoing) activity of hetero-modal brain areas with highest levels of functional connectivity triggers A?-pathology. This model induces the simple question whether in older persons without any cognitive symptoms intrinsic activity of...    »
 
Zeitschriftentitel:
Brain Connect 
Jahr:
2014 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
323-36 
Sprache:
eng 
Print-ISSN:
2158-0014 
TUM Einrichtung:
Klinik und Poliklinik für Psychiatrie und Psychotherapie; Abteilung für Neuroradiologie; Nuklearmedizinische Klinik und Poliklinik